Closed-Loop Systems for the Monitoring and Treatment of Neurodegenerative Disorders


Mohamad Sawan, FRSC, FIEEE, FCAE, FEIC, O.Q.
Chair Professor, Westlake University (西湖大学), China,

Coordinator, Electrical and Information Engineering Program
Founder & Director, CenBRAIN Neurotech, School of Engineering (工学院),

Emeritus Professor, Polytechnique Montreal, Canada.
VP Publications, IEEE-CAS Society
Shilongshan Road No.18, Hangzhou, Zhejiang, China.




Closed-Loop Systems intended for efficient diagnosis and treatment of neurodegenerative diseases are targets to mimic brain regular operation. Consequently, neuromorphic based learning techniques are the heart parts of emerging control units to be embedded in proposed Neuromodulation Systems. This talk covers the implementation of custom devices intended for the diagnosis, treatment, and prediction of health conditions.   It includes signal processing methods, custom integrated circuits and subsequent use to implement wearable and implantable bioelectronic closed-loop systems for brain interfaces.  These methods deal with multidimensional design challenges such as efficient power management, low-power and high-data rate wireless communication methods, small volume devices, reliable wearable, and implantable systems. In these neuromodulation  applications, priority could be given to non-invasive approaches, however for some healthcare dysfunctions, wearable systems can not apply, implantable devices should be used. Also, optoelectronic methods are becoming the winning approaches to build proposed advanced closed-loop systems for both non-invasive nanoimaging, and transcranial stimulation.  Case studies include several applications such as epilepsy, vision, addictions.




Mohamad Sawan is Chair Professor in Westlake University, Hangzhou, China, and Emeritus Professor in Polytechnique Montreal, Canada. He is founder and director of the Center of Excellence in Biomedical Research on Advanced Integrated-on-chips Neurotechnologies (CenBRAIN Neurotech) in Westlake University, Hangzhou, China. Also, he is founder of the Polystim Neurotech Laboratory in Polytechnique Montréal. He received the Ph.D. degree from University of Sherbrooke, Canada. Dr. Sawan research activities are bridging micro/nano electronics with biomedical engineering to introduce smart medical devices dedicated to improving the quality of human life. He was Editor-in-Chief of the IEEE Transactions on Biomedical Circuits and Systems (2016-2019).  He hosted the 2016 IEEE International Symposium on Circuits and Systems, and the 2020 IEEE International Medicine, Biology and Engineering Conference (EMBC). He was a Canada Research Chair in Smart Medical Devices (2001-2015), and was leading the Microsystems Strategic Alliance of Quebec, Canada (1999-2018). Dr. Sawan published more than 1000 peer reviewed papers and many books and patents. He received the Zhejiang Westlake Friendship Award, the Chinese National Friendship Award, the Shanghai International Collaboration Award, the Queen Elizabeth II Golden Jubilee Medal. Dr. Sawan is Fellow of the IEEE, Fellow of the Royal Society of Canada, Fellow of the Canadian Academy of Engineering, and “Officer” of the National Order of Quebec.